Thanks to the presence of IP 6 between silver shell and core gold, show high storage stability. In this work, silver shell was formed on the core gold nanoparticles protected with inositol hexaphosphate (IP 6), designated as which is used as surface enhanced Raman scattering (SERS) substrate. It is urged to develop the rapid and sensitive method for monitoring PG residue in food products. The abuse of Penicillin G (PG) in the feeds of livestock resulted in health risk for human being via the food chain. Thus, this silent region SERS barcode-based suspension array is a developmental advance for modern multiplexed biodetection, potentially providing a powerful early disease screening and diagnosis tool. Detection in patient serum samples demonstrated good consistency with the standard electrochemiluminescence method. Due to synergistic SERS effects from the plasmonic shell and the multi-branched Au nanoflower nanostructure, the reporting signal was greatly improved, enabling ultrasensitive detection of 5-plexed lung cancer markers. The well-designed shell morphology and plasmonic microbead composition enabled significant surface enhancement Raman scattering (SERS) such that we were able to adjust silent region Raman-coding intensity levels. To address these limitations, we constructed a Raman suspension array system using plasmonic microbeads as barcode substrates and Au nanoflowers as reporter carriers. Raman mode is a promising substitute, but the complex spectral peak distributions and extremely weak intrinsic signal intensity severely diminish Raman signal performance in suspension arrays. Current fluorescence suspension arrays are limited by a multiplexed coding ceiling and difficulties with ultrasensitive detection. Suspension arrays are a critical components of next generation multiplexed detection technologies.
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